Aspirin and Diflunisal as cancer agents - experiences and evidence status
10.00 - 11.00 GMT
Prof Joachim Drevs
In many clinical studies, Aspirin is well proven for its preventive and adjuvant efficacy in all types of solid cancers. A similar salicylic acid, Diflunisal, has been used by us in a compassionate use programme since 2011. The particular mechanism of action of Diflunisal is highly effective, as demonstrated in patients with various cancer types, where a swift reduction in tumour burden has been observed. Additionally, this treatment has a secondary mode of action involving the immune system. The treatment protocol typically consists of five cycles, each lasting five days, and is generally well-tolerated. Despite its potent anticancer effects, the treatment's safety profile is considered favourable. Preliminary data from a pilot study suggest promising outcomes, with an approximate response rate of >60% for partial or complete remission and around 30% of patients achieving lasting remissions, regardless of tumour origin.