For over 30 years, The Really Healthy Company has been supplying natural and specialist food supplements, primarily to practitioners and their clients. Our flagship product, Biobran MGN-3 from Japan, is a professional immunomodulator supported by over 70 peer-reviewed studies and three decades of clinical use. Developed by Daiwa Pharmaceutical, this standardised and non-toxic arabinoxylan supplement has been used in clinics and hospitals in Japan, the USA, and Europe. Daiwa also produces natto NKCP, providing the benefits of Natto Bacilli extract for vascular health.
Our diverse portfolio includes PRL's extensive practitioner range of naturally-sourced nutritional formulations; and Medpro's prostate supplements: ProstaSol, Imupros, Prostectan, Imusan and Indole-3-Carbinol. Our own excipient-free Alpha supplement range features premium-quality ingredients, including AlphaGuard (antioxidant protection), AlphaProst (prostate support), AlphaClear (zeolite and chlorella cleanse), and AlphaCurcumin with highly absorbable Longvida curcumin. We also offer MycoNutri mushroom (Cordyceps, Lion’s Mane, Reishi) and Red Yeast Rice extracts; practitioner-strength Artemisinin Extra; PhytoCalm for natural sleep support; Micromax gut reconditioner from the Alps for microbiome health and vitality; Augmented NAC for SP-protein detoxification; and the original UK-introduced wild superfood, organic Klamath Blue Green Algae.

BioBran MGN-3: The Leading Natural Solution for Immune Support

Developed over 30 years ago by Daiwa Pharmaceutical Co. Ltd. in Japan, BioBran MGN-3 is supported by more than 70 peer-reviewed research papers and extensive clinical use. It has become a preferred choice for practitioners seeking reliable immune support. Much of this research has been conducted by Professor Mamdooh Ghoneum, an immunologist at Drew University of Medicine and Science in Los Angeles, USA, and this research is ongoing. (The latest research is looking at the effects of this natural supplement on brain health and how it can be supportive with cognitive decline.)
Manufacture

BioBran MGN-3 is produced through a patented enzymatic process that transforms indigestible rice bran into short-chain polysaccharides, primarily arabinoxylan. Shiitake mushroom enzymes are utilised, with the mushroom mycelia removed post-process. This standardised method ensures batch-to-batch consistency, making BioBran MGN-3 a reliable addition to practitioner protocols.
Immune System Response

When mixed in liquid and ingested (it is pleasant tasting, which encourages compliance), BioBran MGN-3 safely stimulates cytokines—interferons, interleukins, and tumour necrosis factors—that regulate immune responses. This stimulation activates lymphocytes such as NK cells, T cells, and B cells without causing overstimulation or imbalance, making it suitable even for individuals with autoimmune conditions.

As a robust immune system is vital for overall health—protecting against pathogens, infections, and abnormal cells—it is often a central focus in practitioner protocols. Chronic stress, illness, or intensive treatments can compromise immunity, making supplementation with a reliable immunomodulator especially valuable.

Unlike many immune supplements driven by marketing claims, BioBran MGN-3 is scientifically validated and standardised. The same proprietary arabinoxylan used in studies is found in every BioBran MGN-3 box, enhancing practitioner confidence in the product.

Safety and Contraindications

BioBran MGN-3 has no reported toxicity or adverse side effects, even at higher doses taken over extended periods. Notably, it does not lead to a hypo-responsive tail-off, making it suitable as a long-term supplement.

Although shiitake enzymes are used during production, the final product contains no detectable mushroom content, making it safe for those with mushroom allergies. It is officially approved by the Japanese Health Food and Nutrition Food Association. The only clear contraindication is with immunosuppressant medications.

Available Forms

BioBran MGN-3 is available in tablet form (250 mg) and powder sachets (1,000 mg). Tablets offer convenience at lower doses, while powders are preferred for higher intake.

Recommended Dosages:

1. General immune support: 500 mg daily

2. Enhanced immune support: 1,000 mg daily

3. Strongest support: 3,000 mg daily for one month, followed by 1,000 mg daily for maintenance

For optimal results, BioBran MGN-3 should be taken with water, and for the tablets, after a meal. Higher doses should be divided into three portions and taken throughout the day. A healthcare consultation is recommended prior to use, particularly alongside other therapies.
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